Investigation of the interaction mechanism of the marine peptide, such as conotoxins and tachyplesin, based on a combination of computational biology, synthetic chemistry and electrophysiology, establishing the structure-activity relationship of conotoxins at the atomic level. Further optimization of the potency and selectivity of the conotoxins;

Peptide drug design from the naturally occurring or de novo designed constrained peptide;

Gating mechanism study of the ion channels based on molecular dynamics simulations and mutagenesis studies.